Francesco Corrado, MD: Investigating Whether Administering CAR-T Cells Earlier in Disease Course Increases Efficacy: Part 1

Francesco Corrado explained the research question from the oral abstract he presented at ASH 2025, where he and a group of researchers at the Dana-Farber Cancer Institute investigated the efficacy of CAR-T cells when administered at an earlier stage of the disease.

MORE ASH 2025 CONFERENCE COVERAGE:

Nayda Bidikian, MD: Analyzing Immune Cells in Patients with Smoldering Myeloma and Multiple Myeloma

Nayda Bidikian shared data from her oral abstract presentation, saying their group found that patients with earlier stages of disease, such as smoldering myeloma, might have better immune fitness compared to patients with progressed disease who have undergone several therapies.

Francesco Corrado, MD: Investigating Whether Administering CAR-T Cells Earlier in Disease Course Increases Efficacy: Part 2

Francesco Corrado elaborated on the results of his research, noting their findings suggest that intervening with these therapies earlier in the disease treatment could lead to better clinical outcomes.

Nayda Bidikian, MD: Profiling the Immune System in Patients Across Different Stages of Multiple Myeloma

Nayda Bidikian discusses the oral abstract she presented at ASH 2025, where she talked about how because immune dysregulation worsens in multiple myeloma as the disease progresses, they profiled patients’s immune system with peripheral blood samples and compared their status posttreatment to baseline.

Romanos Sklavenitis-Pistofidis, MD: Assessing Biomarkers in Smoldering Myeloma and Multiple Myeloma

Romanos Sklavenitis-Pistofidis, MD, discusses that now that patients with smoldering myeloma have a treatment option as standard of care, it changes the landscape and how healthcare professionals consider genomic and immune biomarkers in this patient population.

Rodger Tiedemann, MD, PhD: The Cell of Origin of Multiple Myeloma

Rodger Tiedemann, MD, PhD, discusses several translocations that can occur in myleoma, noting that B cells from the germinal center are sometimes the carrier of clonal mutations.

Rodger Tiedemann, MD, PhD: Investigating Whether Myeloma Progenitor Cells Contain All the Point Mutations Found in Myeloma

Rodger Tiedemann, MD, PhD, investigated whether the plasma cells pre-treatment give rise to the plasma cells after tretament. He found that in many cases, myeloma plasma cells at relapse can arise from the pre-treatment myeloma B cell compartment, and not necessarily from the myeloma plasma cells.

Romanos Sklavenitis-Pistofidis, MD: The Use of Genomic and Immune Biomarkers to Predict Progression from MGUS and Smoldering Multiple Myeloma to Overt Multiple Myeloma

Romanos Sklavenitis-Pistofidis, MD, shares the advances in the field of genomic biomarkers throughout the year, citing whole genome sequencing–based risk stratification tools that were published.