Matthew Galsky, MD: Unmet Needs and Recent Developments in High-Risk NMIBC

Dr. Galsky discusses unmet needs for patients with high-risk non-muscle invasive bladder cancer (NMIBC). He provides an overview of treatment developments, including the recent approval of durvalumab plus Bacillus Calmette–Guérin (BCG) induction and maintenance on the basis of the POTOMAC trial.

MORE EXPERT PERSPECTIVES IN BLADDER CANCERS:

Gautam Jayram, MD: NIAGARA Trial Data Signal Survival Gains in Muscle Invasive Bladder Cancer: Urologist’s POV

Dr. Gautam Jayram highlights how adding durvalumab to standard gemcitabine–cisplatin chemotherapy in the NIAGARA trial improves event-free and overall survival without significantly increasing toxicity, reinforcing the value of a perioperative “sandwich” approach. He emphasizes the need to address ongoing undertreatment in community settings and advocates for a multidisciplinary strategy to optimize outcomes in patients with muscle-invasive bladder cancer.

Petros Grivas, MD, PhD: Overview of NIAGARA Trial Data for Muscle Invasive Bladder Cancer

Petros Grivas, MD, PhD, of the University of Washington and Fred Hutch Cancer Center, reviewed the data from the Phase 3 NIAGARA trial, which demonstrated that adding durvalumab to neoadjuvant gemcitabine and cisplatin (GC) chemotherapy, followed by adjuvant durvalumab, significantly prolonged event-free and overall survival in cisplatin-eligible patients with localized muscle invasive bladder cancer.
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