Research Summary: Many estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2–) breast tumors develop resistance to aromatase inhibitors (AIs) alone or in combination with a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. However, the capacity for selective ER degraders (SERDs) to induce ER alpha degradation...
Read MoreResearch Summary: Muscle invasive bladder cancer (MIBC) is an aggressive subtype of bladder cancer that invades the musculature of the bladder wall. Current standard treatment involves neoadjuvant chemotherapy followed by radical cystectomy, but MIBC carries a high risk of recurrence, with about half of patients...
Read MoreResearch Summary: KRAS G12C mutations occur in a substantial subset of advanced non-small cell lung cancer (NSCLC), and current first-line standards based on immune checkpoint inhibitors (ICIs), with or without chemotherapy, yield suboptimal long-term outcomes. Olomorasib is an orally bioavailable, highly selective KRAS G12C inhibitor...
Read MoreResearch Summary: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are B-cell malignancies that frequently affect older adults and often require prolonged use of Bruton tyrosine kinase inhibitor (BTKi) therapy in the relapsed or refractory (R/R) setting. Ibrutinib and acalabrutinib are both recommended BTKis...
Read MoreResearch Summary: Capivasertib is a potent, selective inhibitor of all three protein kinase B (AKT1/2/3) isoforms. The phosphoinositide 3- kinase/protein kinase B pathway is frequently overactivated in many solid tumors, including hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) breast cancer. In the...
Read MoreResearch Summary: Covalent Bruton tyrosine kinase (BTK) inhibitors have become the preferred treatment for chronic lymphocytic leukemia (CLL). However, the first-generation BTK inhibitor ibrutinib, though effective, has been associated with cardiac toxicity, including atrial fibrillation, heart failure, and sudden death. Acalabrutinib, a second-generation, more selective...
Read MoreResearch Summary: Accurate prognostic assessment in patients with cutaneous melanoma is essential as it is one of the most prevalent malignancies in the United States. The American Joint Committee on Cancer (AJCC) staging system remains the cornerstone of risk stratification, but outcomes vary widely among...
Read MoreResearch Summary: Cutaneous melanoma is a significant public health concern, as it is the fifth most common cancer in the United States. Traditional prognostic assessment relies on clinicopathologic features such as Breslow thickness, ulceration status, and mitotic rate, but these factors do not always accurately...
Read More
Dr. Gautam Jayram highlights how adding durvalumab to standard gemcitabine–cisplatin...
Read More
Dr. Haley Ellis discusses efficacy data from the TOPAZ-1 clinical...
Read More
Stephanie Gregory, MS, FNP-C, BMTCN, and Jacob Bartlett, PA-C, from...
Read More
Dr. Midhun Malla discusses the evolving treatment landscape for advanced...
Read More
Petros Grivas, MD, PhD, of the University of Washington and...
Read More
Hagen Kennecke, a medical oncologist and professor of medicine at...
Read More
Josh Meyer, MD, of Fox Chase Cancer Center in Philadelphia,...
Read More
Geoffrey Ku, MD, of the Memorial Sloan Kettering Cancer Center,...
Read More
Lisa Hwa Christenson, APRN, DNP, CNP, FAPO, and Miriam Hobbs,...
Read More
Lisa Hwa Christenson, APRN, DNP, CNP, FAPO, and Miriam Hobbs,...
Read More
Dr. Brigle discusses a few pearls for clinicians to consider...
Read More
Daniela Molena, MD, of the Memorial Sloan Kettering Cancer Center,...
Read More©2026 Oncology Matrix. All Rights Reserved.
