Research Summary: KRAS G12C mutations occur in a substantial subset of advanced non-small cell lung cancer (NSCLC), and current first-line standards based on immune checkpoint inhibitors (ICIs), with or without chemotherapy, yield suboptimal long-term outcomes. Olomorasib is an orally bioavailable, highly selective KRAS G12C inhibitor...
Read MoreResearch Summary: Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are B-cell malignancies that frequently affect older adults and often require prolonged use of Bruton tyrosine kinase inhibitor (BTKi) therapy in the relapsed or refractory (R/R) setting. Ibrutinib and acalabrutinib are both recommended BTKis...
Read MoreResearch Summary: Capivasertib is a potent, selective inhibitor of all three protein kinase B (AKT1/2/3) isoforms. The phosphoinositide 3- kinase/protein kinase B pathway is frequently overactivated in many solid tumors, including hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) breast cancer. In the...
Read MoreResearch Summary: Covalent Bruton tyrosine kinase (BTK) inhibitors have become the preferred treatment for chronic lymphocytic leukemia (CLL). However, the first-generation BTK inhibitor ibrutinib, though effective, has been associated with cardiac toxicity, including atrial fibrillation, heart failure, and sudden death. Acalabrutinib, a second-generation, more selective...
Read MoreResearch Summary: Accurate prognostic assessment in patients with cutaneous melanoma is essential as it is one of the most prevalent malignancies in the United States. The American Joint Committee on Cancer (AJCC) staging system remains the cornerstone of risk stratification, but outcomes vary widely among...
Read MoreResearch Summary: Cutaneous melanoma is a significant public health concern, as it is the fifth most common cancer in the United States. Traditional prognostic assessment relies on clinicopathologic features such as Breslow thickness, ulceration status, and mitotic rate, but these factors do not always accurately...
Read More
Josh Meyer, MD, of Fox Chase Cancer Center in Philadelphia,...
Read More
Monica White, RN, shares the purpose of bone marrow biopsy...
Read More
Dr. Vincent Xu discusses the safety and tolerability outcomes from...
Read More
Nilo Azad, MD, a medical oncologist at Johns Hopkins, highlighted...
Read More
Geoffrey Ku, MD, of the Memorial Sloan Kettering Cancer Center,...
Read More
Samantha Shenoy, MS, MSN, ACNP-BC, provides findings on the long-term...
Read More
Rodger Tiedemann, MD, PhD, discusses several translocations that can occur...
Read More
Dr. Brigle discusses a few pearls for clinicians to consider...
Read More©2026 Oncology Matrix. All Rights Reserved.
